High-dose methotrexate-induced epidermal necrosis in two pediatric patients.
Document Type
Article
Publication Title
Pediatric dermatology
Abstract
Methotrexate-induced epidermal necrosis (MEN) is an uncommon but potentially fatal complication. We present two pediatric oncology patients, a 5-year-old girl and a 3-year-old boy, who developed MEN from high-dose methotrexate therapy for pre-B-cell acute lymphocytic leukemia. Following administration of systemic methotrexate, the patients developed erythematous lesions with subsequent skin erosions. Pre-medication with systemic corticosteroids and administration of folinic acid rescue following the methotrexate infusion allowed both patients to resume their chemotherapy regimen with methotrexate.
First Page
659
Last Page
663
DOI
10.1111/pde.14591
Publication Date
5-1-2021
Recommended Citation
Ravi M, Ridpath A, Audino AN, Guinipero T, Chung C, Fernandez Faith E. High-dose methotrexate-induced epidermal necrosis in two pediatric patients. Pediatr Dermatol. 2021 May;38(3):659-663. doi: 10.1111/pde.14591. Epub 2021 Apr 7. PMID: 33829537.