Document Type
Article
Publication Title
Journal of perinatology : official journal of the California Perinatal Association
Abstract
OBJECTIVE: To test the hypothesis that infants born < 30 weeks' gestation supported by Seattle-PAP will have lower rates of continuous positive airway pressure (CPAP) failure than infants supported with conventional, Fisher&Paykel-CPAP (FP-CPAP).
STUDY DESIGN: Randomized trial (3/2017-01/2019) at 5 NICUs. The primary outcome was CPAP failure; subgroup analyses (gestational age, receipt antenatal corticosteroids) were performed.
RESULTS: A total of 232 infants were randomized. Infants in the Seattle-PAP and FP-CPAP groups had mean gestational ages of 27.0 and 27.2 weeks, respectively. We observed no differences in rates of treatment failure between Seattle-PAP (40/112, 35.7%) and FP-CPAP (38/120, 31.7%; risk difference, 4.1%; 95% CI, -8.1-16.2; P = 0.51). Subgroup analysis indicated no differences in rates of CPAP failure. We observed no differences between the two groups in frequencies of adverse events or duration of respiratory support.
CONCLUSIONS: Among infants born < 30 weeks' gestation, rates of CPAP failure did not differ between Seattle-PAP and FP-CPAP.
First Page
1193
Last Page
1201
DOI
10.1038/s41372-020-0690-5
Publication Date
8-1-2020
Recommended Citation
Backes CH, Cooper JN, Notestine JL, Alfred CM, Ball MK, Rivera BK, Lamp JM, Marzec L, Stenger MR, Moallem M, Miller RR, Naik A, Beer LJ, Howard CR, Welty SE, Peter Richardson C, Hillman NH, Zupancic JAF, Stanberry LI, Hansen TN, Smith CV. A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants. J Perinatol. 2020 Aug;40(8):1193-1201. doi: 10.1038/s41372-020-0690-5. Epub 2020 May 20. PMID: 32433510; PMCID: PMC7375950.