The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans.
Document Type
Article
Publication Title
Journal of diabetes and its complications
Abstract
OBJECTIVE: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA).
RESEARCH DESIGN AND METHODS: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female). Insulin sensitivity index (S
RESULTS: Higher TG/HDL-C ratio was associated with IR in Hispanic and AA men and women (P < 0.0002), as well as β-cell function in Hispanic women and AA men and women (P < 0.02). TG/HDL-C predicted incident type 2 diabetes in women (area under the curves 0.703 and 0.795 for Hispanics and AA respectively).
CONCLUSIONS: Similar to Caucasians, the TG/HDL-C ratio can be used to identify IR in Hispanics and AA, and may predict type 2 diabetes in women.
First Page
118
Last Page
122
DOI
10.1016/j.jdiacomp.2018.10.018
Publication Date
2-1-2019
Recommended Citation
Young KA, Maturu A, Lorenzo C, Langefeld CD, Wagenknecht LE, Chen YI, Taylor KD, Rotter JI, Norris JM, Rasouli N. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans. J Diabetes Complications. 2019 Feb;33(2):118-122. doi: 10.1016/j.jdiacomp.2018.10.018. Epub 2018 Nov 3. PMID: 30522790; PMCID: PMC6331279.