Practical Guidance for Systemic Treatment Selection in Pediatric Refractory Atopic Dermatitis.

Document Type

Article

Publication Title

Immunology and allergy clinics of North America

Abstract

Severe or refractory pediatric atopic dermatitis (AD) requires systemic intervention. While severity was historically quantified using physician-administered tools, recent guidelines emphasize patient-centered impacts like pruritus, sleep disturbance, and special site involvement, which heavily affect development and quality of life. Furthermore, treatment is undergoing a paradigm shift, moving away from traditional, broad immunosuppressants (like methotrexate and cyclosporine) toward novel systemic agents. This article reviews the expanding therapeutic spectrum for managing pediatric refractory AD.

First Page

639

Last Page

651

DOI

10.1016/j.iac.2026.06.006

Publication Date

11-1-2026

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