Document Type
Article
Publication Title
JACC Advances
Abstract
The Canadian Cardiovascular Society recently put forth a new classification of acute reperfused myocardial infarction (MI) based on stages of myocardial injury. Backed by more than 5 decades of intense investigation in the field, the key message of this new classification is that not all MIs are the same and that the type and extent of myocardial injury should be considered in diagnosing and treating MI. We review the literature with the goal of highlighting the progressive advances that enabled the synthesis of the Canadian Cardiovascular Society classification into 4 distinct stages of tissue injury. We emphasize the major breakthroughs from insights gained from experimental, translational, and clinical studies to date. We also identify current gaps in knowledge and critical research directions that need to be pursued to improve patient care and reduce post-MI complications such as chronic heart failure and malignant arrhythmias, whose risk is linked to stage and extent of myocardial injury.
First Page
101528
Last Page
101528
DOI
10.1016/j.jacadv.2024.101528
Publication Date
2-1-2025
Recommended Citation
Dharmakumar R, Kloner RA, Fishbein M, Heusch G, Vora KP, Gropler R, Henry T, Shing-Chan F, Singh D, Jambunathan N, Subramanian R, Kreutz RP, Reed GW, Kovacs RJ, Fry E, Kalra A, Kumar A, Raman SV. Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond. JACC Adv. 2025 Feb;4(2):101528. doi: 10.1016/j.jacadv.2024.101528. PMID: 40021272; PMCID: PMC11905164.