Document Type
Article
Publication Title
Stroke research and treatment
Abstract
Background and Purpose. Anticoagulant therapy is broadly used to prevent thromboembolic events. Intracranial hemorrhages are serious complications of anticoagulation, especially with warfarin. Direct oral anticoagulants reduce but do not eliminate the risk of intracranial hemorrhages. The aim of this study is to determine the degree of intracranial hemorrhage after application of anticoagulants without additional triggers. Methods. Rats were treated with different anticoagulant classes (vitamin K antagonists, heparin, direct thrombin inhibitor, and factor Xa inhibitor). Brain hemorrhages were assessed by the free hemoglobin concentration in the brain parenchyma. Results. Vitamin K antagonists (warfarin and brodifacoum) significantly increased free hemoglobin in the brain. Among direct oral anticoagulants, thrombin inhibitor dabigatran also significantly increased free hemoglobin in the brain, whereas treatment with factor Xa inhibitor rivaroxaban did not have significant effect on the free hemoglobin concentration. Conclusions. Our data indicates that the severity of brain hemorrhages depends on the anticoagulant class and it is more pronounced with vitamin K antagonists.
First Page
6516401
Last Page
6516401
DOI
10.1155/2017/6516401
Publication Date
1-1-2017
Recommended Citation
Ware KM, Feinstein DL, Rubinstein I, Battula P, Otero J, Hebert L, Wang TF, Ivanova A, Chaudhary S, Hemminger J, Brodsky SV. The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data. Stroke Res Treat. 2017;2017:6516401. doi: 10.1155/2017/6516401. Epub 2017 Jul 20. PMID: 28808596; PMCID: PMC5541810.