Document Type
Article
Publication Title
Stroke; a journal of cerebral circulation
Abstract
BACKGROUND: We aimed to investigate whether rescue stenting (RS) following failed mechanical thrombectomy (MT) for acute basilar artery occlusion results in superior functional outcomes and enhanced safety compared with the natural history of failed MT.
METHODS: This retrospective cohort study utilized data from the Posterior Circulation Ischemic Stroke Evaluation: Analyzing Radiographic and Intra-Procedural Predictors for Mechanical Thrombectomy registry, encompassing 8 high-volume centers in the United States and covering the period from 2015 to 2021. Patients with basilar artery occlusion who experienced failed MT (modified Thrombolysis in Cerebral Infarction score of 0-2a after at least 1 attempt of clot retrieval) were categorized based on whether they received additional intervention with RS. The primary outcome was a shift analysis of the 90-day modified Rankin Scale. Multivariable logistic regression was used to assess both efficacy and safety outcomes.
RESULTS: Of a total of 444 patients, 119 presented failed MT and were included in the analysis. The RS group comprised 65 (14.6%) patients, while the control group consisted of 54 (12.2%) patients. After adjusting, the RS group showed a favorable shift in the overall 90-day modified Rankin Scale distribution (adjusted common odds ratio, 4.56 [95% CI, 1.67-12.45];
CONCLUSIONS: Our study demonstrated that RS is associated with improved functional outcomes and reduced mortality in basilar artery occlusion patients presenting MT failure. Further randomized trials are needed to validate these findings.
First Page
401
Last Page
412
DOI
10.1161/STROKEAHA.124.047694
Publication Date
2-1-2025
Recommended Citation
Ortega-Gutierrez, Santiago; Rodriguez-Calienes, Aaron; Mierzwa, Adam T; Galecio-Castillo, Milagros; Dibas, Mahmoud; Al Kasab, Sami; Nelson, Ashley; Jadhav, Ashutosh P; Desai, Shashvat; Toth, Gabor; Alrohimi, Anas; Abdalkader, Mohamad; Klein, Piers; Nguyen, Thanh N; Salahuddin, Hisham; Pandey, Aditya; Koduri, Sravanthi; Vora, Niraj; Aladamat, Nameer; Gharaibeh, Khaled; Afreen, Ehad; Zaidi, Syed; and Jumaa, Mouhammad, "Rescue Stenting for Failed Mechanical Thrombectomy in Acute Basilar Artery Occlusions: Analysis of the PC-SEARCH Registry." (2025). Neuroscience Articles. 31.
https://scholarlyworks.ohiohealth.com/neuroscience-articles/31