Effects of PPAR-γ agonists on oral cancer cell lines: Potential horizons for chemopreventives and adjunctive therapies.
Document Type
Article
Publication Title
Head & neck
Abstract
BACKGROUND: Peroxisome proliferator-activated receptor-gamma (PPAR-γ) activators have anti-cancer effects. Our objective was to determine the effect of PPAR-γ ligands 15-deoxy-D
METHODS: NA and CA9-22 cells were treated in vitro with 15-PGJ
RESULTS: MTT assays demonstrated dose-dependent decreases after 15-PGJ
CONCLUSIONS: Our results suggest these agents, in addition to activating PPAR-γ, can downregulate NF-κB and potentiate apoptosis in oral cancer cells.
First Page
2542
Last Page
2554
DOI
10.1002/hed.26286
Publication Date
9-1-2020
Recommended Citation
Hall JA, Rusten M, Abughazaleh RD, Wuertz B, Souksavong V, Escher P, Ondrey F. Effects of PPAR-γ agonists on oral cancer cell lines: Potential horizons for chemopreventives and adjunctive therapies. Head Neck. 2020 Sep;42(9):2542-2554. doi: 10.1002/hed.26286. Epub 2020 Jun 9. PMID: 32519370; PMCID: PMC7657659.