Document Type
Article
Publication Title
Urology case reports
Abstract
Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages.
First Page
21
Last Page
23
DOI
10.1016/j.eucr.2015.01.002
Publication Date
2-7-2015
Recommended Citation
Spees CK, Kelleher KJ, Abaza R, Clinton SK. Prostate Cancer and Li-Fraumeni Syndrome: Implications for Screening and Therapy. Urol Case Rep. 2015 Feb 7;3(2):21-3. doi: 10.1016/j.eucr.2015.01.002. PMID: 26793489; PMCID: PMC4714266.