Improved Patient-Reported Outcomes With Post-Transplant Cyclophosphamide: A Quality-of-Life Evaluation and 2-Year Outcomes of BMT CTN 1703.
Document Type
Article
Publication Title
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abstract
The BMT CTN 1703 phase III trial confirmed that graft-versus-host disease (GVHD) prophylaxis with post-transplantation cyclophosphamide (PTCy), tacrolimus (Tac), and mycophenolate mofetil (MMF) results in superior GVHD-free, relapse-free survival (GRFS) compared with Tac/methotrexate (MTX) prophylaxis. This companion study assesses the effect of these regimens on patient-reported outcomes (PROs). Using the Lee Chronic GVHD Symptom Score and PROMIS subscales (physical function, GI symptoms, social role satisfaction) as primary end points and hemorrhagic cystitis symptoms and Lee subscales as secondary end points, responses from English and Spanish speakers were analyzed at baseline and days 100, 180, and 365 after transplant. PRO scores were compared between the arms using inverse probability weighted-independent estimating equation models. The PTCy arm had significantly lower scores on the Lee Chronic GVHD Symptom Scale (
First Page
2400921
Last Page
2400921
DOI
DOI: 10.1200/JCO.24.00921
Publication Date
1-3-2025
Recommended Citation
Holtan, Shernan G; Bolaños-Meade, Javier; Al Malki, Monzr M; Wu, Juan; Kitko, Carrie L; Reshef, Ran; Rezvani, Andrew R; Shaffer, Brian C; Solh, Melhem M; Yao, Janny M; Runaas, Lyndsey; Elmariah, Hany; Larkin, Karilyn T; El Jurdi, Najla; Gooptu, Mahasweta; Loren, Alison W; Hall, Aric C; Alousi, Amin M; Jamy, Omer; Clark, William; Kean, Leslie; Bhatt, Ami S; Perales, Miguel-Angel; Applegate, Kristy; Efebera, Yvonne Adeduni; Leifer, Eric; Jones, Richard J; Horowitz, Mary M; Mattila, Deborah; Saber, Wael; Hamadani, Mehdi; and Martens, Michael J, "Improved Patient-Reported Outcomes With Post-Transplant Cyclophosphamide: A Quality-of-Life Evaluation and 2-Year Outcomes of BMT CTN 1703." (2025). Oncology Articles. 22.
https://scholarlyworks.ohiohealth.com/oncology-articles/22