Impact of chronic graft-
Document Type
Article
Publication Title
Leukemia & lymphoma
Abstract
Chronic graft-versus-host-disease (cGVHD) is one of the primary causes of morbidity and mortality for patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HCT). In recent years, advancements in allo-HCT have allowed a broader range of patients to receive transplant, particularly older patients. We sought to assess the impact of cGVHD on outcomes in patients undergoing allo-HCT, for older patients as compared to their counterparts. We performed a retrospective analysis of all patients who underwent allo-HCT 1999-2018. Our results showed that those patients who developed cGVHD by D + 180 had an increased risk and incidence of NRM as compared to those patients without cGVHD. There was no significant difference in outcomes for those patients with cGVHD by age (≥60 years old [yo] and <60 yo). These findings suggest the significant morbidity of cGVHD, regardless of age.
First Page
1698
Last Page
1705
DOI
10.1080/10428194.2024.2365910
Publication Date
11-1-2024
Recommended Citation
Jiang, Justin; Sigmund, Audrey M; Zhao, Qiuhong; Elder, Patrick; Vasu, Sumithira; Jaglowski, Samantha; Mims, Alice; Choe, Hannah; Larkin, Karilyn; Wall, Sarah; Grieselhuber, Nicole; William, Basem; Penza, Sam; Benson, Don M; Efebera, Yvonne A; and Sharma, Nidhi, "Impact of chronic graft-" (2024). Oncology Articles. 37.
https://scholarlyworks.ohiohealth.com/oncology-articles/37