Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit.
Document Type
Article
Publication Title
Journal of perinatology : official journal of the California Perinatal Association
Abstract
OBJECTIVE: To identify the relationship between prophylactic indomethacin (PI) administration and incidence of intraventricular hemorrhage.
STUDY DESIGN: A retrospective analysis of extremely premature infants < 27 weeks gestational age born between January 2014 and September 2020.
RESULTS: A total of 421 infants were included from three of Nationwide Children's Hospital delivery centers. Of those 255 (61%) received PI. After adjustment by inverse proportionality treatment weighting (IPTW), no differences were found in incidence of intraventricular hemorrhage (IVH) at the time of the first ultrasound, 31% vs. 33% in PI and control groups respectively (p = 0.68). The rate of rise of serum creatinine from baseline to day of life four was significantly higher in the PI group (0.14 mg/dl PI and 0.03 mg/dl control, p < 0.001).
CONCLUSION: PI was not associated with any benefit in prevention of IVH, but is associated with adverse effects including acute rise in creatinine.
First Page
1644
Last Page
1648
DOI
10.1038/s41372-022-01441-2
Publication Date
12-1-2022
Recommended Citation
Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Dec;42(12):1644-1648. doi: 10.1038/s41372-022-01441-2. Epub 2022 Jun 25. PMID: 35752688.