Document Type
Article
Publication Title
Circ Cardiovasc Interv
Abstract
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative to surgery in patients with severe aortic stenosis, but data are limited on younger, low-risk patients. This analysis compares outcomes in low-surgical-risk patients agedsurgery.
METHODS: The Evolut Low Risk Trial randomized 1414 low-risk patients to treatment with a supra-annular, self-expanding TAVR or surgery. We compared rates of all-cause mortality or disabling stroke, associated clinical outcomes, and bioprosthetic valve performance at 3 years between TAVR and surgery patients aged <75 >years.
RESULTS: In patients <75 >years, 352 were randomized to TAVR and 351 to surgery. Mean age was 69.1±4.0 years (minimum 51 and maximum 74); Society of Thoracic Surgeons Predicted Risk of Mortality was 1.7±0.6%. At 3 years, all-cause mortality or disabling stroke for TAVR was 5.7% and 8.0% for surgery (
CONCLUSIONS: Low-risk patientssupra-annular, self-expanding TAVR had comparable 3-year all-cause mortality and lower disabling stroke compared with patients treated with surgery. There was significantly better valve performance in patients treated with TAVR.
REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT02701283.
First Page
014018
Last Page
014018
DOI
10.1161/CIRCINTERVENTIONS.124.014018
Publication Date
11-1-2024
Recommended Citation
Modine, Thomas; Tchétché, Didier; Van Mieghem, Nicolas M; Deeb, G Michael; Chetcuti, Stanley J; Yakubov, Steven J; Sorajja, Paul; Gada, Hemal; Mumtaz, Mubashir; Ramlawi, Basel; Bajwa, Tanvir; Crouch, John; Teirstein, Paul S; Kleiman, Neal S; Iskander, Ayman; Bagur, Rodrigo; Chu, Michael W A; Berthoumieu, Pierre; Sudre, Arnaud; Adrichem, Rik; Ito, Saki; Huang, Jian; Popma, Jeffrey J; Forrest, John K; and Reardon, Michael J, "Three-Year Outcomes Following TAVR in Younger (<75 >Years) Low-Surgical-Risk Severe Aortic Stenosis Patients." (2024). Heart and Vascular Articles. 84.
https://scholarlyworks.ohiohealth.com/heart-vascular-articles/84